A Stealthy Harvard Startup Wants To Reverse Aging in Dogs, and Humans Could Be Next
A Stealthy Harvard Startup Wants To Reverse Aging in Dogs, and Humans Could Be Next
Published on May 09, 2018 at 04:05PM
The idea is simple, if you ask biologist George Church. He wants to live to 130 in the body of a 22-year-old. From a report: The world's most influential synthetic biologist is behind a new company that plans to rejuvenate dogs using gene therapy. If it works, he plans to try the same approach in people, and he might be one of the first volunteers. The stealth startup Rejuvenate Bio, cofounded by George Church of Harvard Medical School, thinks dogs aren't just man's best friend but also the best way to bring age-defeating treatments to market. The company, which has carried out preliminary tests on beagles, claims it will make animals "younger" by adding new DNA instructions to their bodies. Its age-reversal plans build on tantalizing clues seen in simple organisms like worms and flies. Tweaking their genes can increase their life spans by double or better. Other research has shown that giving old mice blood transfusions from young ones can restore some biomarkers to youthful levels. "We have already done a bunch of trials in mice and we are doing some in dogs, and then we'll move on to humans," Church told the podcaster Rob Reid earlier this year. The company's efforts to keep its activities out of the press make it unclear how many dogs it has treated so far. In a document provided by a West Coast veterinarian, dated last June, Rejuvenate said its gene therapy had been tested on four beagles with Tufts Veterinary School in Boston. It is unclear whether wider tests are under way. However, from public documents, a patent application filed by Harvard, interviews with investors and dog breeders, and public comments made by the founders, MIT Technology Review assembled a portrait of a life-extension startup pursuing a longevity long shot through the $72-billion-a-year US pet industry. "Dogs are a market in and of themselves," Church said during an event in Boston last week. "It's not just a big organism close to humans. It's something people will pay for, and the FDA process is much faster. We'll do dog trials, and that'll be a product, and that'll pay for scaling up in human trials."
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Published on May 09, 2018 at 04:05PM
The idea is simple, if you ask biologist George Church. He wants to live to 130 in the body of a 22-year-old. From a report: The world's most influential synthetic biologist is behind a new company that plans to rejuvenate dogs using gene therapy. If it works, he plans to try the same approach in people, and he might be one of the first volunteers. The stealth startup Rejuvenate Bio, cofounded by George Church of Harvard Medical School, thinks dogs aren't just man's best friend but also the best way to bring age-defeating treatments to market. The company, which has carried out preliminary tests on beagles, claims it will make animals "younger" by adding new DNA instructions to their bodies. Its age-reversal plans build on tantalizing clues seen in simple organisms like worms and flies. Tweaking their genes can increase their life spans by double or better. Other research has shown that giving old mice blood transfusions from young ones can restore some biomarkers to youthful levels. "We have already done a bunch of trials in mice and we are doing some in dogs, and then we'll move on to humans," Church told the podcaster Rob Reid earlier this year. The company's efforts to keep its activities out of the press make it unclear how many dogs it has treated so far. In a document provided by a West Coast veterinarian, dated last June, Rejuvenate said its gene therapy had been tested on four beagles with Tufts Veterinary School in Boston. It is unclear whether wider tests are under way. However, from public documents, a patent application filed by Harvard, interviews with investors and dog breeders, and public comments made by the founders, MIT Technology Review assembled a portrait of a life-extension startup pursuing a longevity long shot through the $72-billion-a-year US pet industry. "Dogs are a market in and of themselves," Church said during an event in Boston last week. "It's not just a big organism close to humans. It's something people will pay for, and the FDA process is much faster. We'll do dog trials, and that'll be a product, and that'll pay for scaling up in human trials."
Read more of this story at Slashdot.
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A Stealthy Harvard Startup Wants To Reverse Aging in Dogs, and Humans Could Be Next
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